Identification of residues in the BST-2 TM domain important for antagonism by HIV-1 Vpu using a gain-of-function approach

The HIV-1 Vpu protein enhances the release of viral particles from the cell surface in a cell-type specific manner.In the absence of Vpu, nascent virions remain tethered to the cell surface in restricted cell types.Recently, the human host factor BST-2/CD317/tetherin was found to be responsible for the inhibition of virus release.It was also report

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Multilevel effects of light on ribosome dynamics in chloroplasts program genome-wide and psbA-specific changes in translation.

Plants and algae adapt to fluctuating light conditions to optimize photosynthesis, minimize photodamage, and prioritize energy investments.Changes in the translation of chloroplast mRNAs are known to contribute to these adaptations, but the scope and magnitude of these responses are unclear.To clarify the phenomenology, we used ribosome profiling t

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